Monday, May 12, 2008

Green Tea’s EGCG May Inhibit Breast Cancer Growth

Researchers from the University of Mississippi Medical Center found that green tea’s main antioxidant, EGCG, significantly decreased factors associated with breast cancer: vascular endothelial growth factor (VEGF) expression, tumor angiogenesis, and growth of the breast cancer tumor (p<0.01).

In the study, seven week old female mice were given approximately 50-100 mg/kg/day of EGCG in water; the control group received regular drinking water. Breast cancer cells were injected in the second week of the five week study.

At the end of five weeks, several differences were seen between control and treatment groups. The tumors in the EGCG group were significantly smaller (66%) and weighed less (68%); in addition, this group had significantly lower levels of VEGF (p<0.01 for all results).

These findings were presented at April’s Experimental Biology meeting, a multi-society, interdisciplinary, scientific meeting featuring plenary and award lectures, symposia, oral and poster sessions, career services, and exhibits of scientific equipment, supplies, and publications. Gu JW, Young E, Covington J, Johnson JW, & Tan W. Oral administration of EGCG, an antioxidant found in green tea, inhibits tumor angiogenesis and growth of breast cancer in female mice. Poster session presented at the annual Experimental Biology scientific conferences, San Diego, CA. 2008.

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